Engineering Adaptive (bio) Materials from Functional Polymers and Peptide Stereocomplexes
ABSTRACT
Fall
Graphene-based Materials for Applications in Heterogeneous Catalysis, Water Treatment and Solar Water Desalination
This talk will address the development of three classes of graphene-based materials as (1) support for metal nanoparticle catalysts in heterogeneous catalysis, (2) sorbent materials for the removal of heavy metal ions from polluted water, and (3) photothermal energy converter materials for efficient solar water desalination.
Escaping Flatland: Synthetic Innovation for the Future of Drug Discovery
ABSTRACT
2018-19 Kick-off Seminar: A Taste of Space: New Recipes for Making Complex Interstellar Molecules
ABSTRACT
Chemistry and Biology of Nucleic Acid- and Nucleotide-Binding Proteins
The functions of nucleotides and nucleic acids involve their interactions with cellular proteins. In this presentation, I will discuss about our recent efforts toward the development and applications of quantitative proteomic methods for unbiased, proteome-wide discovery of proteins that can recognize unique secondary structures of DNA. I will also discuss our recent development of targeted quantitative proteomic methods for interrogating ATP- and GTP-binding proteins at the entire proteome scale.
Instrumented Tissue-in-a-Chip: A Bridge from In Vitro to In Vivo
Abstract:
Jefferson Lecture: New Photoredox Reactions
Abstract
New Chemical Probe Technologies: Applications to Imaging, Target Identification and Drug Discovery
Hydrolases are enzymes that often play important roles in many common human diseases such as cancer, asthma, arthritis, atherosclerosis and infection by pathogens. Therefore tools that can be used to dynamically monitor their activity can be used as diagnostic agents, as imaging contrast agents and for the identification of novel classes of drugs. In the first part of this presentation, I will describe our efforts to design and synthesize small molecule probes that produce a fluorescent signal upon binding to tumor associated protease targets.
Spontaneous Formation of Oligomers and Fibrils in Large Scale Molecular Dynamics Simulations of the Alzheimer’s Peptides
Spontaneous Formation of Oligomers and Fibrils in Large-Scale Molecular Dynamics Simulations of the Alzheimer’s Peptides
Highly Sterically-Crowded Subvalent Group 14 Compounds: Unexpected Structures and High Reactivity with Small Molecules
A series of new compounds, MAr2 (M = Ge, Sn, or Pb; Ar = terphenyl ligands) display structures and structural trends that are counter-intuitive with regard to steric effects. These trends are also reflected in their spectroscopic properties and in their reaction chemistry. It was found that the presence or absence of substituents at apparently-remote sites on the ligands can exert a large influence on the course of the reactions, as well as on the structural characteristics of the group 14 element environment.
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