Upcoming Seminars

All seminars are held at 3:30 PM in the Mechanical Engineering Building (MEC) Room 205 unless otherwise noted.

Fall 2019

Oct
23

Magnesium(I) Dimers: Universal Reductants for the Synthetic/Catalytic Chemist?

Magnesium(I) Dimers: Universal Reductants for the Synthetic/Catalytic Chemist?

Professor Cameron Jones | Monash University: Director, Monash Centre for Catalysis

Professor Robert Gilliard

ABSTRACT

The renaissance that has occurred in main group chemistry over the last several decades has been largely driven by the realization that very low oxidation state p-block compounds can be stable species at ambient temperature, given the right ligand environment. Increasingly, such compounds are being shown to possess "transition metal-like" reactivity patterns in small molecule activations, and associated catalytic synthetic transformations.[1] In late 2007 we extended this field to the s-block with the preparation of the first room temperature stable molecular compounds containing magnesium-magnesium covalent bonds, viz. LMgMgL (L = bulky guanidinate or b-diketiminate, e.g. 1).[2] We have subsequently shown that the unique properties these species possess lend them to use as versatile reducing agents in both organic and inorganic synthetic protocols.[3] The products of such reactions are often inaccessible using more classical reducing agents. In this lecture an overview of what has been achieved with these remarkable reagents will be given, with an emphasis placed on the preparation of unprecedented examples of low oxidation state/low coordination number metal-metal bonded complexes involving metals from the s-, p- and d-blocks, e.g. 2-4.[4] The further chemistry of these highly reactive systems will also be discussed, as will our efforts to incorporate magnesium(I) dimers into catalytic cycles.[5]

 

REFERENCES

[1] Power, P. P. Nature 2010, 463, 171.

[2] Green, S. P.; Jones, C.; Stasch, A. Science 2007, 305, 1136.

[3] Jones, C. Nature Rev. Chem. 2017, 1, 0059.

[4] Bonyhady, S.J.; Collis, D.; Holzmann, N.; Edwards, A.J.; Piltz, R.O.; Frenking, G.; Stasch, A.; Jones, C. Nature Comm., 2018, 9, 3079.

[5] (a) Boutland, A. J.; Carroll, A.; Lamsfus, C. A.; Stasch, A.; Maron, L.; Jones, C. J. Am. Chem. Soc. 2017, 139, 18190; (b) Yuvaraj, K.; Douair, I.; Paparo, A.; Maron, L.; Jones, C. J. Am. Chem. Soc., 2019, 141, 8764.

Professor Cameron Jones | Monash University: Director, Monash Centre for Catalysis
Hosted by Professor Robert Gilliard
Oct
25

Chemical Biology and Chemistry for Translational Lipid Biology and Beyond

Chemical Biology and Chemistry for Translational Lipid Biology and Beyond

Professor Ken Hsu | UVA Department of Chemistry

Professor Linda Columbus

ABSTRACT

Lipids represent a rich model system for understanding how nature maintains cellular architecture (membrane building blocks), bioenergetics (energy stores), and communication (secondary messengers) through fine adjustments in enzyme metabolism. Embedded within lipid structures is chemical information that define their metabolic fate and function. Elucidating structure-function relationships of lipids in biological systems has been traditionally challenging because of the massive structural diversity of lipids in nature and lack of tools to selectively probe their function in vivo. I will describe efforts from my group to use chemical biology and mass spectrometry to gain fundamental insights into diacylglycerol (DAG) biology and the translational potential of modulating DAG pathways in inflammation and immuno-oncology.

Professor Ken Hsu | UVA Department of Chemistry
Hosted by Professor Linda Columbus
Nov
01

Proton-Coupled Electron Transfer by Copper-Oxygen Species Relevant to Enzyme Intermediates

Proton-Coupled Electron Transfer by Copper-Oxygen Species Relevant to Enzyme Intermediates

Professor William Tolman | Washington University in St. Louis

Professor Charlie Machan

Characterization of copper intermediates in enzymes and other catalysts that attack strong C-H bonds is important for unraveling oxidation catalysis mechanisms and, ultimately, designing new, more efficient catalytic systems. New insights into the nature of such intermediates may be obtained through the design, synthesis, and characterization of copper-oxygen complexes. Two key proposed examples contain [CuO2]+ and [CuOH]2+ cores, which have been suggested as possible reactive intermediates in monocopper enzymes such as lytic polysaccharide monooxygenase. Recent progress toward the characterization of the structures and properties of complexes with these cores that feature the same supporting ligand will be described, and detailed comparisons of their kinetics in reactions with C-H and O-H bonds will be discussed. Notable differences in their PCET reaction pathways with para-substituted phenols has been discovered that shed new light on the fundamental chemistry of these important core structures.

Professor William Tolman | Washington University in St. Louis
Hosted by Professor Charlie Machan
Nov
08

Main Group Lewis Acids for Applications in Catalysis and Anion Transport

Main Group Lewis Acids for Applications in Catalysis and Anion Transport

Professor François Gabbaï | Texas A & M University

Professor Robert Gilliard

ABSTRACT

Main group Lewis acids for applications in catalysis and anion transport

Research in the Gabbaï group has been dedicated to the synthesis and study of Lewis acidic main group compounds with the development of applications in molecular recognition and catalysis as the ultimate goals.  This seminar will highlight a series of recent results obtained in pursuit of these goals.  The first part of the presentation will focus on the chemistry of antimony- and carbon-based Z-type ligands and their demonstrated ability to modulate the catalytic reactivity of adjacent metal centers.  The second part of the presentation will show how boron and antimony-based Lewis acids can be deployed in aqueous media to effectively transport a range of anions across phospholipid bilayers in artificial vesicles as well as in live cells.

Professor François Gabbaï | Texas A & M University
Hosted by Professor Robert Gilliard
Nov
15

Professor Richard Olson | Bristol-Myers Squibb

Professor Richard Olson | Bristol-Myers Squibb

Professor Ken Hsu
Hosted by Professor Ken Hsu
Nov
22

DATE IS AVAILABLE

DATE IS AVAILABLE

Spring 2020

Jan
17

DATE IS AVAILABLE

DATE IS AVAILABLE

Jan
22

WEDNESDAY: DATE IS AVAILABLE

WEDNESDAY: DATE IS AVAILABLE

Jan
24

Re-imagining the Periodic Table: Sustainable Catalysis for the 21st Century

Re-imagining the Periodic Table: Sustainable Catalysis for the 21st Century

Dr. Paul Chirik | Princeton University

Graduate Student Council
Dr. Paul Chirik | Princeton University
Hosted by Graduate Student Council
Jan
31

Dr. Mike Roper | Florida State University

Dr. Mike Roper | Florida State University

Professor James Landers
Hosted by Professor James Landers
Feb
14

Dr. Hien Nguyen| Wayne State University

Dr. Hien Nguyen| Wayne State University

Professor Clifford Stains
Hosted by Professor Clifford Stains
Feb
19

Dr. Eric Rivard | University of Alberta

Dr. Eric Rivard | University of Alberta

Professor Robert Gilliard
Hosted by Professor Robert Gilliard
Feb
21

Dr. Aaron Dinner | University of Chicago

Dr. Aaron Dinner | University of Chicago

Professor Kateri DuBay
Hosted by Professor Kateri DuBay
Feb
28

Dr. Mitch Antsey | Davidson College

Dr. Mitch Antsey | Davidson College

Professor Charlie Machan
Hosted by Professor Charlie Machan
Mar
06

Dr. Ray Schaak | Penn State University

Dr. Ray Schaak | Penn State University

Professor Sen Zhang
Hosted by Professor Sen Zhang
Mar
18

Dr. Bhavya Sharma | University of Tennessee (Wed Talk)

Dr. Bhavya Sharma | University of Tennessee (Wed Talk)

Professor Jill Venton
Hosted by Professor Jill Venton
Mar
20

Dr. Jin Zhang | University of California, San Diego (Wed Talk)

Dr. Jin Zhang | University of California, San Diego (Wed Talk)

Professor Andreas Gahlmann
Hosted by Professor Andreas Gahlmann
Mar
25

Professor Professor Piotr Zelenay | Los Alamos National Laboratory (Wed.)

Professor Professor Piotr Zelenay | Los Alamos National Laboratory (Wed.)

Professor Sen Zhang
Hosted by Professor Sen Zhang
Mar
27

Taming Protein Condensation

Taming Protein Condensation

Dr. Ying Wang | University of North Carolina-Wilmington

Professor Huiwang Ai
Dr. Ying Wang | University of North Carolina-Wilmington
Hosted by Professor Huiwang Ai
Apr
03

GRADUATE RECRUITMENT WEEK: NO SEMINAR

GRADUATE RECRUITMENT WEEK: NO SEMINAR

Apr
10

Annual Hecht Lecture

Annual Hecht Lecture

Dr. Frank Bennett | Ionis Pharmaceuticals

Professor Sidney Hecht
Dr. Frank Bennett | Ionis Pharmaceuticals
Hosted by Professor Sidney Hecht
Apr
15

Dr. Julie Kovacs | University of Washington (Wed Talk)

Dr. Julie Kovacs | University of Washington (Wed Talk)

Professor Charlie Machan
Hosted by Professor Charlie Machan
Apr
17

Tentative Date for ACS Poster Session

Tentative Date for ACS Poster Session

Apr
22

WEDNESDAY: DATE IS AVAILABLE

WEDNESDAY: DATE IS AVAILABLE

Apr
24

TBA

TBA

Dr. Jill Millstone | University of Pittsburgh

Professor Charlie Machan
Dr. Jill Millstone | University of Pittsburgh
Hosted by Professor Charlie Machan

2019

Feb
05

WEDNESDAY: DATE IS AVAILABLE

WEDNESDAY: DATE IS AVAILABLE