Olfactory Receptors in Vascular Macrophages Drive Atherosclerosis by NLRP3-Dependent IL-1 Production

Atherosclerosis is an inflammatory disease of the arterial wall driven by macrophages and other immune cells. Olfactory receptors (OLFRs) are G-protein coupled receptors expressed primarily in olfactory epithelium and are responsible for the sense of smell. OLFRs expressed in multiple extra-nasal tissues have been implicated in diverse biological processes. Here we show that mouse vascular macrophages express many olfactory receptors including Olfr2 (also known as I7), a receptor for octanal.

Chemical Engineering Approaches for Catalytic Reduction of CO2

Rising atmospheric concentration of CO2 is forecasted to have potentially disastrous effects on the environment from its role in global warming and ocean acidification.  Converting CO2 into valuable chemicals and fuels is one of the most practical routes for reducing CO2 emissions while fossil fuels continue to dominate the energy sector.  In the past few years our group has investigated the catalytic reduction of CO2 using a combination of kinetic studies, in situ characterization and density functional theory calculations.  In this talk we will present several examples on (1) CO2

Burger Lecture | Harnessing Chemistry to Understand the Roles of Glycans in Neuroplasticity

The field of chemical neurobiology is providing insights into the molecules and interactions involved in neuronal development, sensory perception, and memory storage. In this talk, I will describe the development of chemical tools to understand how glycosaminoglycans contribute to neuroplasticity – the ability of the brain to adapt and form new neural connections.


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