Alvarez Pari (Beginning August-2025)
Research
Organic Chemistry and Synthesis
Sun
Ou
Newkirk
Levitt
Hertle
Ma
With the continuous development of mass spectrometry imaging (MSI)-based tools for spatially resolved metabolomics and disease screening and diagnosis, challenges remain and appear. We are aiming to develop new versatile MSI platforms and apply them into different bioanalytical applications: 1. Three-dimensional, high-sensitivity laser-based platform for single cell or tissue MSI studies, 2. In-situ structural elucidations of metabolites, lipids and glycans in MSI experiments without extensive tissue derivatization and instrument modifications, and 3.
Tepe
Organic and Medicinal Chemistry
Research in our lab is an interdisciplinary blend of synthetic organic chemistry, medicinal chemistry, and pharmacology.
Total Synthesis of Natural Products
Natural products represent a highly diverse and structurally complex natural library of compounds with remarkable biological and medicinal properties. Our lab develops new chemical methodologies to prepare natural products and natural product mimics with the goal of unraveling new mechanisms of protein regulation and their medicinal implications.
Chruma
Professor Chruma is teaching organic chemistry lecture and laboratory courses, with a particular focus on organic laboratory for non-majors/minors on a pre-health career track. Over the past two decades, he established a highly collaborative international research portfolio in organic synthesis. Independent research interests involved the development of new methods for the synthesis of biologically-active natural products, drug-like scaffolds, and luminescent small molecules, with a particular focus on using 2-azaallyl anions as imine umpolungs and super-electron-donors. Moreover, Prof.
Harman
For decades, the dearomatization of arenes has been recognized as a chemical transformation of fundamental importance. It provides the connection between this robust and abundant source of hydrocarbons and the alicyclic frameworks common to many biologically active products. Thus, dearomatization methods have become powerful tools for organic synthesis.
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