Professor Ken Hsu is featured in the Future of Biochemistry, the special issue of the ACS publication Biochemistry. This special issue features the work of 44 Junior Faculty that were selected from across the globe who are combining an ever-diversifying set of skills and backgrounds to tackle problems of biochemical relevance. See the Introductory Editorial and Dedication that lists Professor Ken Hsu here.
White phosphorus (P4) has been the traditional entry point into phosphorus chemistry. The thirteenth element to have been isolated, it can be oxidized with elemental oxygen or chlorine, or reduced in a variety of ways. We investigated its reduction using early transition metal systems and breakdown to produce complexes with terminal metal-phosphorus triple bonds. Such terminal phosphide complexes possess nucleophilic phosphorus atoms, paving the way to new phosphorus-element bonded systems.
Cells are poised to respond to their physical environment and to chemical stimuli in terms of collective molecular interactions that are regulated in time and space by the plasma membrane and its connections with the cytoskeleton and intracellular structures. Small molecules may engage specific receptors to initiate a transmembrane signal, and the surrounding system efficiently rearranges to amplify this nanoscale interaction to microscale assemblies, yielding a cellular response that often reaches to longer length scales within the organism.
Abstract: Access to global public healthcare is impacted by many technical, economic, and social factors. It is widely recognized that the resources required to deliver and improve global public health are currently constrained. A powerful way to increase access is to lower the cost of products and services that have already proven to be effective. Currently, the cost of producing a wide range of pharmaceutical products is higher than it needs to be.