Featured News

The Pompano Lab's research was featured in C&E News' coverage of the national ACS Conference.

Featured Students

Adam Borne has been awarded the 2018 Wagner Fellowship award. He is one of 14 students receiving the award this year.

Featured Faculty

Professor Emeritus Lester Andrews has been honored with a Festschrift Virtual Special Issue of the Journal of Physical Chemistry A.


Reductive Carboxylation of Unsaturated Hydrocarbons with CO2

Reductive Carboxylation of Unsaturated Hydrocarbons with CO2

Professor Brian Popp | West Virginia University

Hosted by Professor Mike Hilinski


Carbon dioxide is an attractive C1 synthon in chemical synthesis due to its abundance, obtainability, non-toxicity, and inherent renewability. However, it has been undervalued and underutilized for the synthetic installation of carboxyl functionality because of its unreactive nature, owing to its inherent thermodynamic stability and kinetic inertness. Traditionally the carboxyl group is accessed by organic chemists through redox manipulation and protection/deprotection reactions or through the use of strong nucleophiles that have limited functional group tolerance. By fixing carbon dioxide with unsaturated organic molecules through C–C bond formation, rapid and redox-economic synthesis of carboxylic acids and their derivatives can be realized. Nevertheless, these transformations remain rare, are poorly understood, and generally limited to more energetic alkyne substrates. The Popp Research Group uses methodological and mechanistic approaches to expand the versatility and usefulness of transition metal-catalyzed reductive olefin carboxylation. Two approaches that will be discussed in this seminar are transfer hydrometallation–carboxylation and hetero(element)carboxylation. Recent mechanistic work will be presented on an iron-catalyzed variant of the former reaction class that has revealed new details, and possibly new opportunities, for this poorly understood class of reaction. The latter manifold was only recently extended by our group to include olefins (vinyl arenes) for the first time (ACS Editors’ Choice–Org. Lett. 2016, 18, 6428). The mild method uses redox-neutral copper catalysis and a single atmosphere of CO2 to obtain boron-functionalized α-aryl carboxylic acids, including novel functionalized-NSAIDs such as bora-ibuprofen and bora-naproxen. Recent progress toward the preparation of new bora-olefin compounds, subsequent synthetic elaboration of the carbon-boron bond, and complementary experimental/computational studies to improve our mechanistic understanding of the reaction will also be presented.

Friday, September 7, 2018
Graham Lecture (title TBA)

Graham Lecture (title TBA)

Professor Frank Gupton | Virginia Commonwealth University

Hosted by Professor Brooks Pate
Thursday, September 13, 2018


Professor Lucy Ziurys | University of Arizona

Hosted by Professor Rob Garrod
Friday, September 21, 2018

Alumni Corner

Join our online network groups, keep us updated, and support faculty research, scholarships and fellowships. Read More...