Department of Chemistry

Chemistry and Biology of Nucleic Acid- and Nucleotide-Binding Proteins

The functions of nucleotides and nucleic acids involve their interactions with cellular proteins.  In this presentation, I will discuss about our recent efforts toward the development and applications of quantitative proteomic methods for unbiased, proteome-wide discovery of proteins that can recognize unique secondary structures of DNA. I will also discuss our recent development of targeted quantitative proteomic methods for interrogating ATP- and GTP-binding proteins at the entire proteome scale.

Cindy Knight receives the 2018 Leonard W. Sandridge Outstanding Contribution Award!

Cindy Knight has been named recipient of the 2018 Leonard W. Sandridge Outstanding Contribution Award. This is the most prestigious award that a staff member can earn. Her award includes Dinner at the Boar’s head with President Sullivan, a lunch with the Board of Visitors, and consideration for nomination for Governor’s Awards.

Selection Criteria

• Outstanding contribution to the overall mission, objectives, and values of the University

New Chemical Probe Technologies: Applications to Imaging, Target Identification and Drug Discovery

Hydrolases are enzymes that often play important roles in many common human diseases such as cancer, asthma, arthritis, atherosclerosis and infection by pathogens. Therefore tools that can be used to dynamically monitor their activity can be used as diagnostic agents, as imaging contrast agents and for the identification of novel classes of drugs. In the first part of this presentation, I will describe our efforts to design and synthesize small molecule probes that produce a fluorescent signal upon binding to tumor associated protease targets.

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