Our lab develops methods based on microfluidic culture systems, bioanalytical techniques, and spatially resolved simulations to quantify the spatiotemporal dynamics of the inflammatory cascade and develop targeted therapies. This work is part of a broad interest in the dynamics of complex biological systems. Specifically, we study the kinetics of immunity and inflammation, and we develop chemically targeted methods to control these processes in the context of vaccination, autoimmunity, and chronic inflammatory disease.
Vibrational Dynamics and the Spectroscopy of Highly Excited Molecules
Lisa Morkowchuk is an instructor for Introductory College Chemistry lecture (1410/1610) and laboratories (1411/1611). She received a B.S. in Chemistry from Moravian College in Bethlehem, Pennsylvania and a Ph.D. in Chemistry from Rensselaer Polytechnic Institute in Troy, New York. Much of her undergraduate education was presented in a guided-inquiry format, and she quickly realized the value of peer interaction in education and the depth of understanding that comes from inquiry-based learning.
The Machan group is interested in energy-relevant catalysis, particularly at the interface of molecular electrochemistry and materials. The development of efficient and selective transformations to produce commodity chemical precursors and fuels using CO2, O2, H2, and H2O as reagents remains an ongoing challenge for the storage of electrical energy within chemical bonds. Our approach is inspired by the numerous metalloproteins capable of catalyzing kinetically challenging reactions with significant energy barriers in an efficient manner under ambient conditions.
The pharmacological mechanism of action of small molecules and on the fundamental biological role of protein tyrosine phosphatases in disease.
Polyethylene Terephthalate Microdevices
My laboratory aims to integrate state-of-the-art chemical biology and mass spectrometry to address fundamental challenges associated with studying the regulation of lipid metabolism and signaling in vivo. Our goal is to develop new chemical and bioanalytical methods to understand pathways of metabolic regulation and translate these findings into new therapeutic strategies for human disease. To achieve our goals, we synthesize and apply small molecule probes and inhibitors to detect and inactivate metabolic enzymes and pathways in living systems.
The science of organic synthesis is central to both the discovery and manufacturing of pharmaceuticals and other fine chemicals and the emergence of subdisciplines of biology that are becoming increasingly focused on phenomena at the molecular level (e.g., synthetic biology and chemical biology). Over the last half-century revolutionary advances in synthetic organic chemistry have made it possible to synthesize virtually any molecule given enough time, money, and manpower.