Our lab develops methods based on microfluidic culture systems, bioanalytical techniques, and spatially resolved simulations to quantify the spatiotemporal dynamics of the inflammatory cascade and develop targeted therapies. This work is part of a broad interest in the dynamics of complex biological systems. Specifically, we study the kinetics of immunity and inflammation, and we develop chemically targeted methods to control these processes in the context of vaccination, autoimmunity, and chronic inflammatory disease.
Vibrational Dynamics and the Spectroscopy of Highly Excited Molecules
Structure, Function & Evolution of Ribonucleoprotein Assemblies
The Mura lab employs experimental and computational approaches to understand the structure, function/dynamics, and evolution of RNA- and DNA-based protein assemblies. In particular, we seek a deeper understanding of Sm-based ribonucleoprotein (RNP) assemblies; what these protein/RNA complexes look like at atomic resolution (structure, such as shown below), their assembly pathways and dynamical behavior (function), and the interrelationships between Sm and Sm-like systems (evolution).
Lisa Morkowchuk is an instructor for Introductory College Chemistry lecture (1410/1610) and laboratories (1411/1611). She received a B.S. in Chemistry from Moravian College in Bethlehem, Pennsylvania and a Ph.D. in Chemistry from Rensselaer Polytechnic Institute in Troy, New York. Much of her undergraduate education was presented in a guided-inquiry format, and she quickly realized the value of peer interaction in education and the depth of understanding that comes from inquiry-based learning.
Chem 1410/1420 (general chemistry)
Chem 2821 (honors chemistry 4th semester lab)
The Machan group is interested in energy-relevant catalysis, particularly at the interface of molecular electrochemistry and materials. The development of efficient and selective transformations to produce commodity chemical precursors and fuels using CO2, O2, H2, and H2O as reagents remains an ongoing challenge for the storage of electrical energy within chemical bonds. Our approach is inspired by the numerous metalloproteins capable of catalyzing kinetically challenging reactions with significant energy barriers in an efficient manner under ambient conditions.
Bioorganic and Synthetic Organic Chemistry
The pharmacological mechanism of action of small molecules and on the fundamental biological role of protein tyrosine phosphatases in disease.