Organic Chemistry and Synthesis

Fraser

Research in the Fraser Lab is concerned with materials chemistry—synthesis, properties, and applications, along with environmental, health and societal impacts. While developing routes to polymeric metal complexes—well-defined hybrid inorganic-organic materials inspired by metalloproteins, combining coordination chemistry and controlled polymerization—we made two important discoveries involving luminescent boron complexes.  Difluoroboron β-diketonate dyes show intense fluorescence, 2-photon absorption, and environment sensitive emission.

Bushweller

Our lab is fundamentally interested in understanding, from a structural and biophysical perspective, the functioning of proteins involved in regulating transcription, particularly those involved in the dysregulation associated with the development of cancer. Structural and functional characterization of the native forms of these proteins and their relevant complexes via NMR spectroscopy, X-ray crystallography, and a variety of other techniques provides a baseline of understanding.

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