Design and Application of Chemical Biology Tools for Studying Cellular Communication
Organic Chemistry and Synthesis
Alicia Frantz is an instructor for Organic Chemistry lecture. She earned a B.S. in Forensic Chemistry and a Ph.D. in Chemistry from Ohio University, Athens, Ohio. She is currently focusing on implementation of guided inquiry based learning in courses with large enrollment. Attending a large school herself, Alicia understands the importance for dedicating more of class time to group work and evidence-based techniques than the traditional lecturing.
Chemical Biology; Fluorescence and Bioluminescence Imaging; Protein Engineering
Professor Kevin Welch is interested in developing curricula for undergraduate instruction in general chemistry and organic chemistry. In particular, his focus is on updating these courses to accommodate the diverse educational background in chemistry of the students enrolling in chemistry at the University of Virginia, as well as providing a strong chemical foundation for the students as they continue on in their educational and post-educational careers in a variety of fields. In the past, he has taught undergraduate courses in general chemistry, organic chemistry, inorganic chemistry, en
Professor Serbulea is teaching organic chemistry courses, including the accelerated organic chemistry lectures and laboratories. She is actively involved in the development of the organic chemistry curriculum, focusing on improving the coordination between the topics in the lecture course and the experiments that are carried out in the laboratory. In the accelerated organic chemistry laboratories, students gain hands-on experience in the synthesis, purification, and characterization of organic compounds using modern analytical instruments and laboratory equipment.
Organic, Polymer and Organometallic Chemistry; Asymmetric Catalysis; Chiral Sensors; Optically Active Materials
Bioorganic and Synthetic Organic Chemistry
My laboratory aims to integrate state-of-the-art chemical biology and mass spectrometry to address fundamental challenges associated with studying the regulation of lipid metabolism and signaling in vivo. Our goal is to develop new chemical and bioanalytical methods to understand pathways of metabolic regulation and translate these findings into new therapeutic strategies for human disease. To achieve our goals, we synthesize and apply small molecule probes and inhibitors to detect and inactivate metabolic enzymes and pathways in living systems.
The science of organic synthesis is central to both the discovery and manufacturing of pharmaceuticals and other fine chemicals and the emergence of subdisciplines of biology that are becoming increasingly focused on phenomena at the molecular level (e.g., synthetic biology and chemical biology). Over the last half-century revolutionary advances in synthetic organic chemistry have made it possible to synthesize virtually any molecule given enough time, money, and manpower.
For decades, the dearomatization of arenes has been recognized as a chemical transformation of fundamental importance. It provides the connection between this robust and abundant source of hydrocarbons and the alicyclic frameworks common to many biologically active products. Thus, dearomatization methods have become powerful tools for organic synthesis.